studies grouped by ingredient

CATUABA

  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Yohimbine. 2020 Apr 5. PMID: 31644013.
  • Campos MM, Fernandes ES, Ferreira J, Santos AR, Calixto JB. Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology (Berl). 2005 Oct;182(1):45-53. doi: 10.1007/s00213-005-0052-1. Epub 2005 Sep 29. PMID: 15991001.
  • Martins NO, de Brito IM, Araújo SSO, Negri G, Carlini EA, Mendes FR. Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba). BMC Complement Altern Med. 2018 Jun 5;18(1):172. doi: 10.1186/s12906-018-2222-9. PMID: 29866157; PMCID: PMC5987406.
  • Martins NO, de Brito IM, Araújo SSO, Negri G, Carlini EA, Mendes FR. Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba). BMC Complement Altern Med. 2018 Jun 5;18(1):172. doi: 10.1186/s12906-018-2222-9. PMID: 29866157; PMCID: PMC5987406.

CHAGA

DAMIANA

  • Kotta S, Ansari SH, Ali J. Exploring scientifically proven herbal aphrodisiacs. Pharmacogn Rev. 2013 Jan;7(13):1-10. doi: 10.4103/0973-7847.112832. PMID: 23922450; PMCID: PMC3731873.
  • Estrada-Reyes R, Ortiz-López P, Gutiérrez-Ortíz J, Martínez-Mota L. Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males. J Ethnopharmacol. 2009 Jun 25;123(3):423-9. doi: 10.1016/j.jep.2009.03.032. Epub 2009 Mar 31. PMID: 19501274.
  • Powers, C., et al. "A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements." In Silico Pharmacol. 2015 Mar; 3: 4.
  • Zhao, J., et al. "Anti-aromatase activity of the constituents from damiana (Turnera diffusa)." J. Ethnopharmacol. 2008 Dec; 120(3): 387-93.
  • Zava, D., et al. "Estrogen and progestin bioactivity of foods, herbs and spices." Proc. Soc. Exp. Biol. Med. 1998; 217(3): 369-78.
  • Kwitowska, J., et al. "Turnera diffusa Willd. ex Schult. as medicinal plant." Postepy. Fitoterapii. 2015 Apr; 237-243.
    Estrada-Reyes, R, et al. "Pro-sexual effects of Turnera diffusa Wild (Turneraceae) in male rats involves the nitric oxide pathway." J. Ethnopharmacol. 2013 Mar; 146(1): 164-72.
  • Singh, R., et al. "Some medicinal plants with aphrodisiac potential: A current status." J. Acute. Dis. 2013; 179-188.
    da Silva, C., et al. "Phytochemistry of some Brazilian Plants with aphrodisiac activity, phytochemicals - a global perspective of their role in nutrition and health." Dr. Venketeshwer Rao (Ed.), 2012.
  • Patel, D., et al. "Pharmacologically screened aphrodisiac plant-A review of current scientific literature." Asian Pac. J. Trop. Biomed. 2011 Sep; 1(1)Sup: S131-S138.
  • Feistel, B., et al. "Damiana (Turnera diffusa Willd.) – a traditionally used aphrodisiac as modern PDE-5 inhibitor." Planta Med. 2010; 76 - P002.
  • Kumar, S., et al. "Evaluation of aphrodisiac activity of Turnera aphrodisiaca." Int. J. Pharmacogn. Phytochem Res 2009; 1(1): 1-4.
  • Estrada-Reyes, R., et al. "Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males." J. Ethnopharmacol. 2009 Jun 25; 123(3): 423-9.
  • Kumar, S., et al. "Pharmacognostic standardization of Turnera aphrodisiaca Ward." J. Med. Food. 2006 Summer; 9(2): 254-60.
  • Rowland, D., et al. "A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions." J. Sex. Marital Ther. 2003 May-Jun; 29(3): 185-205.
  • Helmrick, L., et al. "Aphrodisiac properties of Turnera diffusa." J. Undergrad. Res. 2000; 9-13.
  • Arletti, R., et al. "Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual-behavior of male rats." Psychopharmacology. 1999; 143(1): 15-19.

EPIMEDIUM

KANNA

LION'S MANE

MATCHA

NIACIN

PINE POLLEN

  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Yohimbine. 2020 Apr 5. PMID: 31644013.
  • Campos MM, Fernandes ES, Ferreira J, Santos AR, Calixto JB. Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology (Berl). 2005 Oct;182(1):45-53. doi: 10.1007/s00213-005-0052-1. Epub 2005 Sep 29. PMID: 15991001.
  • Martins NO, de Brito IM, Araújo SSO, Negri G, Carlini EA, Mendes FR. Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba). BMC Complement Altern Med. 2018 Jun 5;18(1):172. doi: 10.1186/s12906-018-2222-9. PMID: 29866157; PMCID: PMC5987406.
  • Martins NO, de Brito IM, Araújo SSO, Negri G, Carlini EA, Mendes FR. Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba). BMC Complement Altern Med. 2018 Jun 5;18(1):172. doi: 10.1186/s12906-018-2222-9. PMID: 29866157; PMCID: PMC5987406.

REISHI

RHODIOLA

  • Martínez-Pinilla E., Oñatibia-Astibia A., Franco R. (2015). The relevance of theobromine for the beneficial effects of cocoa consumption. Frontiers in pharmacology, 6, 30. doi:10.3389/fphar.2015.00030

  • Yoneda M, Sugimoto N, Katakura M, Matsuzaki K, Tanigami H, Yachie A, Ohno-Shosaku T, Shido O. (2016) Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice. J Nutr Biochem. 2017 Jan;39:110-116. doi: 10.1016/j.jnutbio.2016.10.002. Epub 2016 Oct 8.

  • Islam R, Matsuzaki K, Sumiyoshi E, Hossain ME, Hashimoto M, Katakura M, Sugimoto N, Shido O. (2019) Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats. Nutrients. 2019 Apr 20;11(4). pii: E888. doi: 10.3390/nu11040888.

  • Fernández-Fernández L, Esteban G, Giralt M, Valente T, Bolea I, Solé M, Sun P, Benítez S, Morelló JR, Reguant J, Ramírez B, Hidalgo J, Unzeta M. (2015) Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids. Food Funct. 2015 Apr;6(4):1251-60. doi: 10.1039/c5fo00052a.

  • Mitchell ES, Slettenaar M, vd Meer N, Transler C, Jans L, Quadt F, Berry M. (2011) Differential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure. Physiol Behav. 2011 Oct 24;104(5):816-22. doi: 10.1016/j.physbeh.2011.07.027. Epub 2011 Aug 4.


THEOBROMINE

  • Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. (2000) Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000 Oct;7(5):365-71.

  • Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. (2000) A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9.

  • Olsson EM, von Schéele B, Panossian AG. (2009) A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009 Feb;75(2):105-12. doi: 10.1055/s-0028-1088346. Epub 2008 Nov 18.

  • Kurkin, V. A., Dubishchev, A. V., Ezhkov, V. N., Titova, I. N., & Avdeeva, E. V. (2006). Antidepressant activity of some phytopharmaceuticals and phenylpropanoids. Pharmaceutical Chemistry Journal, 40(11), 614-619.

  • Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. (2007) Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007;61(5):343-8. Erratum in: Nord J Psychiatry. 2007;61(6):503.

  • Perfumi M, Mattioli L. (2007) Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res. 2007 Jan;21(1):37-43.

  • Panossian, A., Nikoyan, N., Ohanyan, N., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E., & Wikman, G. (2008) Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008 Jan;15(1-2):84-91. Epub 2007 Dec 3.

  • Panossian A, Wagner H. (2005) Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res. 2005 Oct;19(10):819-38. Review.

  • Petkov VD, Yonkov D, Mosharoff A, Kambourova T, Alova L, Petkov VV, Todorov I. (1986) Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory. Acta Physiol Pharmacol Bulg. 1986;12(1):3-16.

  • Van Diermen, D., Marston, A., Bravo, J., Reist, M., Carrupt, P. A., & Hostettmann, K. (2009). Monoamine oxidase inhibition by Rhodiola rosea L. roots. Journal of ethnopharmacology, 122(2), 397-401. [animal studies]


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